Roxogesic

Description

• Loxoprofen is the most prescribed of NSAIDs in Japan & East Asia
• Roxogesic is a prodrug with powerful analgesic, antipyretic and anti-inflammatory properties
• Loxoprofen Sodium belongs to NSAID (Nonsteroidal anti-inflammatory drug) class. It has an activity to treat inflammatory rheumatoid diseases and relief acute pain. It is effective against period pains, pain after surgery, and fever

ROXOGESIC is Powerful NSAID

• Clinical trials demonstrate Loxoprofen’s superiority in terms of efficacy & safety as well in comparison to Diclofenac Sod.
• Roxogesic was found useful or extremely useful by patients of Rheumatoid arthritis and osteoarthritis
• The analgesic effect of Roxogesic is 10:20 times more potent than Ketoprofen, Naproxen & Indomethacin

ROXOGESIC is Fast

• The active metabolite of Roxogesic is distributed quickly to the inflamed synovium
• The analgesic effects of Roxogesic were perceived within 15 minutes
• Roxogesic provides faster antipyretic effects than ibuprofen

ROXOGESIC is More Tolerable

• Roxogesic is a prodrug which is rapidly absorbed from the digestive tract in unchanged form and then converted to an active metabolite to minimize gastro-intestinal side effects
• Roxogesic is well tolerated by 97% of patients

Active Ingredient

Loxoprofen Sodium 60mg
Therapeutic Class: Non-steroidal anti-inflammatory drug

Mechanism of Action

• • Loxoprofen is a drug belongs to a class of NSAID (Nonsteroidal anti-inflammatory drug), acts by inhibiting isoforms of cyclo-oxygenase enzyme and Inhibition of prostaglandin biosynthesis constitutes the mechanism of action of this drug

• • When administered orally, Loxoprofen sodium is absorbed from the gastrointestinal tract as an unchanged compound with only a modest gastric-mucosal irritation. It is then rapidly bio-transformed into the active metabolite trans-OH form (SRS coordination) with a potent inhibitory effect on prostaglandin biosynthesis to exert its pharmacologic effects

Indications & Uses

• • Analgesic & Anti-Inflammatory in Degenerative joint disease, Inflammatory joint disease & Acute musculoskeletal disorders

• • Acute pain attacks associated with Trauma (Strains & Sprains), Myositis, Tendonitis, Post-operative, Low Back Pain, Osteoarthritis, Rheumatoid Arthritis, Neck-Shoulder-Arm Syndrome & Chronic articular rheumatism

• • Adjuvant with Antibiotics with U.R.T.I e.g. Pharyngotonsillitis, Sinusitis, Laryngitis & Otitis media, also Flu & Common Cold Symptoms “Pain, Fever & Headache”

• • Antipyretic: fever due to inflammation

• • Pain after tooth extraction

Dosage & Administration

2-3 Tablets per day 

Forms & Strengths

Carton box of 2 blisters, each contains 10 tablets, each tablet contains 68 mg Loxoprofen sodium dehydrate eq. to 60 mg as Loxoprofen sodium

Contraindication & Cautions

Roxogesic is contraindicated in the following patients:

• • Patients with peptic ulcers

• • Patients with severe hematological abnormalities

• • Patients with severe hepatic dysfunction

• • Patients with severe renal dysfunction

• • Patients with severe cardiac function failure

• • Patients with a history of hypersensitivity to any of the components of this product

• • Patients with or with a history of aspirin-induced asthma

• • Women in the late stages of pregnancy

Pregnancy & Breastfeeding

• • There are no adequate and well-controlled studies of Roxogesic in pregnant women, Roxogesic should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus, Roxogesic should not be administered to women during late pregnancy

• • It is not known whether Roxogesic is excreted in human milk, but a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother