is a modified third-generation topical retinoid primarily used in the treatment of mild-moderate acne, it is called novel retinoid because it has a new chemical structure that make it more tolerable and less skin irritation. It Helps normalize hyperkeratinization and have anti-inflammatory effects. Adagel is a comedolytic agent.
Adapalene 0.1% gel
Mechanism of Action
Acts within the nucleus of the cell where they bind with receptors called Retinoic Acid Receptors (RAR) to interact with cellular DNA and cause change in gene expression of epithelial cell growth and differentiation.
Adagel is Selective high affinity binding →RARᵦ and RARɣ
Selectivity of Adapalene gives
low skin irritation
low systemic conc.
potent regulation of epithelial cell growth
Indications & Uses
In the treatment of Acne vulgaris
Dosage & Administration
- applied on affected area once daily at night
Forms & Strengths
Gel 30 gm, Adapalene 0.1%
Contraindications & Cautions
Pregnancy: Category C
Nursing women: Contraindicated because it is unknown if it is excreted in milk or not.